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GPCR

NameMelanin-concentrating hormone receptor 2
SpeciesHomo sapiens (Human)
GeneMCHR2
SynonymG-protein coupled receptor 145
melanin-concentrating hormone receptor 2
MCHR-2
MCH2R
MCH2 receptor
[ Show all ]
DiseaseN/A
Length340
Amino acid sequenceMNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProtQ969V1
Protein Data BankN/A
GPCR-HGmod modelQ969V1
3D structure modelThis predicted structure model is from GPCR-EXP Q969V1.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5038
IUPHAR281
DrugBankN/A

Ligand

NameCHEMBL208688
Molecular formulaC31H28F4N4O2S
IUPAC name3-[4-[2-[5-fluoro-6-(trifluoromethyl)-1H-benzimidazol-2-yl]-6-propan-2-ylsulfonyl-6-azaspiro[2.5]octan-2-yl]phenyl]benzonitrile
Molecular weight596.645
Hydrogen bond acceptor9
Hydrogen bond donor1
XlogP6.4
SynonymsBDBM50186851
SCHEMBL14502098
4''-[1-(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-6-(propane-2-sulfonyl)-6-aza-spiro[2.5]oct-1-yl]-biphenyl-3-carbonitrile
Inchi KeyHKIMHHCVNCTDQD-UHFFFAOYSA-N
Inchi IDInChI=1S/C31H28F4N4O2S/c1-19(2)42(40,41)39-12-10-29(11-13-39)18-30(29,23-8-6-21(7-9-23)22-5-3-4-20(14-22)17-36)28-37-26-15-24(31(33,34)35)25(32)16-27(26)38-28/h3-9,14-16,19H,10-13,18H2,1-2H3,(H,37,38)
PubChem CID11635715
ChEMBLCHEMBL208688
IUPHARN/A
BindingDB50186851
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity<3.0 uMPMID16690315ChEMBL

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