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GPCR

NameBeta-2 adrenergic receptor
SpeciesCanis lupus familiaris (Dog)
GeneADRB2
SynonymBeta-2 adrenoceptor
Beta-2 adrenoreceptor
DiseaseN/A for non-human GPCRs
Length415
Amino acid sequenceMGQPANRSVFLLAPNGSHAPDQGDSQERSEAWVVGMGIVMSLIVLAIVFGNVLVITAIARFERLQTVTNYFITSLACADLVMGLAVVPFGASHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAKETCCDFFTNQAYAIASSIVSFYLPLVVMVFVYSRVFQVAQRQLQKIDRSEGRFHAQNLSQVEQDGRSGHGHRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIPKEVYILLNWVGYVNSAFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSNNSNSRSDYAGEHSGCHLGQEKDSELLCEDPPGTEDRQGTVPSDSVDSQGRNCSTNDSLL
UniProtP54833
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2289
IUPHARN/A
DrugBankN/A

Ligand

Namepropranolol
Molecular formulaC16H21NO2
IUPAC name1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
Molecular weight259.349
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP3.0
SynonymsServanolol
Spectrum4_000974
[2-hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine
NCGC00024690-03
PDSP1_000767
[ Show all ]
Inchi KeyAQHHHDLHHXJYJD-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
PubChem CID4946
ChEMBLCHEMBL27
IUPHAR564
BindingDB25761
DrugBankDB00571

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
DR100.03 mg kg-1PMID6124636ChEMBL
ED500.124 mg.kg-1PMID6138434ChEMBL
IC5017.0 nMPMID1976812BindingDB,ChEMBL
ID500.038 mg.kg-1PMID3001305ChEMBL
Kd1.778 nMPMID6330358ChEMBL
Kd1.78 nMPMID6330358BindingDB
Vasodilation7.95 -PMID2861287ChEMBL

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