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GPCR

NameDelta-type opioid receptor
SpeciesRattus norvegicus (Rat)
GeneOprd1
Synonymopioid receptor
OP1
DOR-1
DOR
DOPr
[ Show all ]
DiseaseN/A for non-human GPCRs
Length372
Amino acid sequenceMEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
UniProtP33533
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL269
IUPHAR317
DrugBankN/A

Ligand

NameCHEMBL146108
Molecular formulaC25H33N3O3
IUPAC name(3S)-2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]-N-tert-butyl-3,4-dihydro-1H-isoquinoline-3-carboxamide
Molecular weight423.557
Hydrogen bond acceptor4
Hydrogen bond donor3
XlogP3.1
Synonyms(S)-2-[(S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid tert-butylamide
BDBM50083165
Inchi KeyASKBYBNQNYTQNX-VXKWHMMOSA-N
Inchi IDInChI=1S/C25H33N3O3/c1-15-10-19(29)11-16(2)20(15)13-21(26)24(31)28-14-18-9-7-6-8-17(18)12-22(28)23(30)27-25(3,4)5/h6-11,21-22,29H,12-14,26H2,1-5H3,(H,27,30)/t21-,22-/m0/s1
PubChem CID10526305
ChEMBLCHEMBL146108
IUPHARN/A
BindingDB50083165
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki0.43 nMPMID10585210BindingDB,ChEMBL
Ki0.93 nMPMID10585210BindingDB,ChEMBL

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