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GLASS

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GPCR

Name	D(1A) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD1
Synonym	D1 receptor D1A DADR Gpcr15 dopamine D1 receptor Dopamine-1A receptor [ Show all ]
Disease	Unspecified Hypertension Pain Parkinson's disease Psychiatric disorder Psychotic disorders Schizophrenia Substance dependence Type 2 diabetes Excessive bleeding following childbirth and spontaneous or elective abortion Cocaine addiction Dementia Cognitive disorders [ Show all ]
Length	446
Amino acid sequence	MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProt	P21728
Protein Data Bank	N/A
GPCR-HGmod model	P21728
3D structure model	This predicted structure model is from GPCR-EXP P21728.
BioLiP	N/A
Therapeutic Target Database	T22118
ChEMBL	CHEMBL2056
IUPHAR	214
DrugBank	BE0000020

Ligand

Name	ADTN
Molecular formula	C10H13NO2
IUPAC name	6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol
Molecular weight	179.219
Hydrogen bond acceptor	3
Hydrogen bond donor	3
XlogP	1.4
Synonyms	Lopac0_000415 NCGC00162147-01 SCHEMBL3126243 53463-78-8 6-azanyl-5,6,7,8-tetrahydronaphthalene-2,3-diol;hydrobromide Biomol-NT_000003 cMAP_000069 KB-199024 KBio2_007647 NCGC00015291-02 NCGC00162147-04 SR-01000075362-6 2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene 6,7-Dihydroxy-3-chromanamine AC1L1FAH CCG-204507 FT-0645288 KBioSS_002519 NCGC00015291-05 PDSP2_000476 (+)-ADTN 2-aminotetralin-6,7-diol;hydrobromide 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol AKOS006328808 cid_11957526 HMS1990C05 LS-175452 NCGC00162147-02 SMR001254097 2,3-Naphthalenediol, 6-amino-5,6,7,8-tetrahydro- 6,7-Adtn BPBio1_001127 CTK4J8115 KBio2_002511 KBio3_002989 NCGC00015291-03 PDSP1_000478 2-Amino-6,7-dihydroxytetralin 6-Amino-5,6,7,8-tetrahydro-2,3-naphthalenediol AC1Q79PY GTPL932 L000081 NCGC00015291-06 PDSP2_000807 (+)-ADTN (aminotetralin-6,7-diol) 463A788 6-amino-5,6,7,8-tetrahydronaphthalene-2,3-diol;hydrobromide BDBM81195 cid_3153 HMS3403C05 KBio2_005079 MLS002172466 NCGC00162147-03 SR-01000075362 2,3-Naphthalenediol,6-amino-5,6,7,8-tetrahydro- 6,7-Dihydroxy-2-aminotetralin BSPBio_001023 D0X2NO KBioGR_002511 NCGC00015291-04 PDSP1_000820 2-aminotetralin-6,7-diol 6-Amino-5,6,7,8-tetrahydro-naphthalene-2,3-diol CHEMBL26736 HMS1792C05 [ Show all ]
Inchi Key	ASXGAOFCKGHGMF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H13NO2/c11-8-2-1-6-4-9(12)10(13)5-7(6)3-8/h4-5,8,12-13H,1-3,11H2
PubChem CID	3153
ChEMBL	CHEMBL26736
IUPHAR	932
BindingDB	81195
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	398.107 - 5011.87 nM	PMID12388666, PMID1826762	IUPHAR
Potency	16.4 nM	PubChem BioAssay data set	ChEMBL
Potency	51.7 nM	PubChem BioAssay data set	ChEMBL
Potency	89.1 nM	PubChem BioAssay data set	ChEMBL
Potency	158.5 nM	PubChem BioAssay data set	ChEMBL

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