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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	5-Hydroxy-2-aminotetralin
Molecular formula	C10H13NO
IUPAC name	6-amino-5,6,7,8-tetrahydronaphthalen-1-ol
Molecular weight	163.22
Hydrogen bond acceptor	2
Hydrogen bond donor	2
XlogP	1.3
Synonyms	1-Naphthalenol, 6-amino-5,6,7,8-tetrahydro- 94425-22-6 W-4440 BDBM50020511 6-amino-5,6,7,8-tetrahydronaphthalen-1-ol CTK2H8461 2-aminotetralin-5-ol AC1L2O3Q 6-Amino-5,6,7,8-tetrahydro-1-naphthalenol 75016-98-7 SCHEMBL265580 AKOS022636612 6-Amino-5,6,7,8-tetrahydro-naphthalen-1-ol CHEMBL441092 [ Show all ]
Inchi Key	AUBNLLGXUCCYFZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H13NO/c11-8-4-5-9-7(6-8)2-1-3-10(9)12/h1-3,8,12H,4-6,11H2
PubChem CID	125156
ChEMBL	CHEMBL441092
IUPHAR	N/A
BindingDB	50020511
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<3333.0 nM	PMID8863800	BindingDB,ChEMBL

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