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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Neuropeptide Y receptor type 2
Species	Homo sapiens (Human)
Gene	NPY2R
Synonym	NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor
Disease	Diabetes Metabolic disorders Obesity
Length	381
Amino acid sequence	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProt	P49146
Protein Data Bank	N/A
GPCR-HGmod model	P49146
3D structure model	This predicted structure model is from GPCR-EXP P49146.
BioLiP	N/A
Therapeutic Target Database	T10670
ChEMBL	CHEMBL4018
IUPHAR	306
DrugBank	BE0002419

Ligand

Name	CHEMBL21992
Molecular formula	C31H31N3O3
IUPAC name	(E)-N-(1-acetyl-2,3-dihydroindol-6-yl)-N-(1-benzoylpiperidin-4-yl)-3-phenylprop-2-enamide
Molecular weight	493.607
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	4.5
Synonyms	SCHEMBL4838882 (E)-N-(1-Acetyl-2,3-dihydro-1H-indol-6-yl)-N-(1-benzoyl-piperidin-4-yl)-3-phenyl-acrylamide SCHEMBL4838896 BDBM50140472
Inchi Key	AVCABACOWGQOCC-NTCAYCPXSA-N
Inchi ID	InChI=1S/C31H31N3O3/c1-23(35)33-21-16-25-13-14-28(22-29(25)33)34(30(36)15-12-24-8-4-2-5-9-24)27-17-19-32(20-18-27)31(37)26-10-6-3-7-11-26/h2-15,22,27H,16-21H2,1H3/b15-12+
PubChem CID	11306461
ChEMBL	CHEMBL21992
IUPHAR	N/A
BindingDB	50140472
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	29000.0 nM	PMID14980673, PMID24365162	BindingDB,ChEMBL

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