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GPCR

NameDelta-type opioid receptor
SpeciesRattus norvegicus (Rat)
GeneOprd1
Synonymopioid receptor
OP1
DOR-1
DOR
DOPr
[ Show all ]
DiseaseN/A for non-human GPCRs
Length372
Amino acid sequenceMEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
UniProtP33533
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL269
IUPHAR317
DrugBankN/A

Ligand

NameCHEMBL2370431
Molecular formulaC28H29N3O5
IUPAC name(2S)-2-[[(3S)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-3-phenylpropanoic acid
Molecular weight487.556
Hydrogen bond acceptor6
Hydrogen bond donor4
XlogP0.7
Synonyms2-{2-[2-amino-3-(4-hydroxyphenyl)-(2S)-propanoyl]-1,2,3,4-tetrahydro-3-isoquinolinylcarboxamido}-3-phenyl-(2S)-propanoic acid
BDBM50041956
2-{2-[2-amino-3-(4-hydroxyphenyl)-(2S)-propanoyl]-1,2,3,4-tetrahydro-3-isoquinolinylmethylamino}-3-phenyl-(2S)-propanoic acid
Inchi KeyAZBAOXFFFLMUBH-SDHOMARFSA-N
Inchi IDInChI=1S/C28H29N3O5/c29-23(14-19-10-12-22(32)13-11-19)27(34)31-17-21-9-5-4-8-20(21)16-25(31)26(33)30-24(28(35)36)15-18-6-2-1-3-7-18/h1-13,23-25,32H,14-17,29H2,(H,30,33)(H,35,36)/t23-,24-,25-/m0/s1
PubChem CID12093958
ChEMBLCHEMBL2370431
IUPHARN/A
BindingDB50041956
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ke8.23 nMPMID8230106ChEMBL
Ke9.06 nMPMID8230106ChEMBL
Ke9.12 nMPMID8230106ChEMBL
Ke11.7 nMPMID8230106ChEMBL
Ke12.6 nMPMID8230106ChEMBL
Ke16.1 nMPMID8230106ChEMBL
Ki1.9 nMPMID8230106BindingDB
Ki1.94 nMPMID8230106ChEMBL
Ki9.07 nMPMID8230106ChEMBL
Ki9.1 nMPMID8230106BindingDB
Potency0.28 -PMID8230106ChEMBL
Potency1.3 -PMID8230106ChEMBL

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