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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 1F
Species	Homo sapiens (Human)
Gene	HTR1F
Synonym	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled serotonin receptor 1F 5-HT-1F 5-HT1Ebeta HTR1EL 5-HT1F 5-HT1F receptor 5-HT6 [ Show all ]
Disease	Migraine
Length	366
Amino acid sequence	MDFLNSSDQNLTSEELLNRMPSKILVSLTLSGLALMTTTINSLVIAAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIVYIVRESWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMITIVWIISVFISMPPLFWRHQGTSRDDECIIKHDHIVSTIYSTFGAFYIPLALILILYYKIYRAAKTLYHKRQASRIAKEEVNGQVLLESGEKSTKSVSTSYVLEKSLSDPSTDFDKIHSTVRSLRSEFKHEKSWRRQKISGTRERKAATTLGLILGAFVICWLPFFVKELVVNVCDKCKISEEMSNFLAWLGYLNSLINPLIYTIFNEDFKKAFQKLVRCRC
UniProt	P30939
Protein Data Bank	N/A
GPCR-HGmod model	P30939
3D structure model	This predicted structure model is from GPCR-EXP P30939.
BioLiP	N/A
Therapeutic Target Database	T78656
ChEMBL	CHEMBL1805
IUPHAR	5
DrugBank	BE0000460, BE0004958

Ligand

Name	LY334370
Molecular formula	C21H22FN3O
IUPAC name	4-fluoro-N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]benzamide
Molecular weight	351.425
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	3.6
Synonyms	182563-08-2 5Q7I1WL2UY D09GHO LY-334370 4-fluoro-N-[3-(1-methyl-4-piperidinyl)-1h-indol-5-yl]-benzamide BDBM50130461 GTPL20 SCHEMBL6911508 4-fluoro-N-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]benzamide CHEMBL101690 LY 334370 [3H]LY334370 AC1NSKBH DTXSID40415518 4-fluoro-n-[3-(1-methyl-4-piperidinyl)-1h-indol-5-yl]benzamide Benzamide, 4-fluoro-N-(3-(1-methyl-4-piperidinyl)-1H-indol-5-yl)- HY-103107 UNII-5Q7I1WL2UY CS-0025021 LY-334,370 4-Fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benzamide BCP29131 GTPL151 NCGC00378776-02 4-Fluoro-N-[3-(1-methyl-piperidin-4-yl)-1H-indol-5-yl]-benzamide L000364 ZINC1488294 [ Show all ]
Inchi Key	MDMJLMDBRQXOOI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H22FN3O/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15/h2-7,12-14,23H,8-11H2,1H3,(H,24,26)
PubChem CID	5311258
ChEMBL	CHEMBL101690
IUPHAR	20, 151
BindingDB	50130461
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kd	0.398 nM	PMID15900510	IUPHAR
Ki	1.6 nM	PMID18507369	PDSP
Ki	1.6 nM	PMID18507369, PMID14684321	BindingDB,ChEMBL
Ki	1.99 nM	PMID15900510	IUPHAR
Ki	2.1 nM	PMID15546719, PMID26271587, PMID12825944	BindingDB,ChEMBL

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