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Name | 5-hydroxytryptamine receptor 1D |
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Species | Homo sapiens (Human) |
Gene | HTR1D |
Synonym | Serotonin 1D alpha receptor serotonin receptor 1D HTRL Htr1db 5-HT-1D [ Show all ] |
Disease | Acute migraine Epilepsy Migraine headaches Mood disorder Migraine [ Show all ] |
Length | 377 |
Amino acid sequence | MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS |
UniProt | P28221 |
Protein Data Bank | N/A |
GPCR-HGmod model | P28221 |
3D structure model | This predicted structure model is from GPCR-EXP P28221. |
BioLiP | N/A |
Therapeutic Target Database | T11072 |
ChEMBL | CHEMBL1983 |
IUPHAR | 3 |
DrugBank | BE0000659 |
Name | CHEMBL350153 |
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Molecular formula | C28H36N4O2 |
IUPAC name | (4S)-4-[[3-[2-[(3S)-3-[[benzyl(methyl)amino]methyl]pyrrolidin-1-yl]ethyl]-1H-indol-5-yl]methyl]-3-methyl-1,3-oxazolidin-2-one |
Molecular weight | 460.622 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 1 |
XlogP | 4.3 |
Synonyms | BDBM50074162 (S)-4-[3-(2-{(S)-3-[(Benzyl-methyl-amino)-methyl]-pyrrolidin-1-yl}-ethyl)-1H-indol-5-ylmethyl]-3-methyl-oxazolidin-2-one |
Inchi Key | BDAPYHMNZXWDPN-ZCYQVOJMSA-N |
Inchi ID | InChI=1S/C28H36N4O2/c1-30(17-21-6-4-3-5-7-21)18-23-10-12-32(19-23)13-11-24-16-29-27-9-8-22(15-26(24)27)14-25-20-34-28(33)31(25)2/h3-9,15-16,23,25,29H,10-14,17-20H2,1-2H3/t23-,25-/m0/s1 |
PubChem CID | 10600063 |
ChEMBL | CHEMBL350153 |
IUPHAR | N/A |
BindingDB | 50074162 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 3.2 nM | PMID10052975 | BindingDB,ChEMBL |
IC50 | 1.7 nM | PMID10052975 | BindingDB,ChEMBL |
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