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GPCR

NameAlpha-2C adrenergic receptor
SpeciesHomo sapiens (Human)
GeneADRA2C
Synonymalpha2-C4
Adra-2c
ADRA2L2
ADRA2RL2
Adrenergic alpha2C- receptor class I
[ Show all ]
DiseaseDiabetic nephropathy; Fibromyalgia
Hypertension
Heart failure
Glaucoma
Alzheimer disease
[ Show all ]
Length462
Amino acid sequenceMASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProtP18825
Protein Data BankN/A
GPCR-HGmod modelP18825
3D structure modelThis predicted structure model is from GPCR-EXP P18825.
BioLiPN/A
Therapeutic Target DatabaseT01777
ChEMBLCHEMBL1916
IUPHAR27
DrugBankBE0004864, BE0000342, BE0004888

Ligand

NameCHEMBL576623
Molecular formulaC14H18N2O
IUPAC name2-[1-(2-cyclopropylphenyl)ethoxy]-4,5-dihydro-1H-imidazole
Molecular weight230.311
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP2.4
SynonymsBDBM50415139
Inchi KeyBGPHEWUAKSHOBD-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H18N2O/c1-10(17-14-15-8-9-16-14)12-4-2-3-5-13(12)11-6-7-11/h2-5,10-11H,6-9H2,1H3,(H,15,16)
PubChem CID45487956
ChEMBLCHEMBL576623
IUPHARN/A
BindingDB50415139
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5039.81 nMPMID19886609ChEMBL
EC5040.0 nMPMID19886609BindingDB
Intrinsic activity0.9 -PMID19886609ChEMBL
Ki79.0 nMPMID19886609BindingDB
Ki79.43 nMPMID19886609ChEMBL

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