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GPCR

NameAlpha-1D adrenergic receptor
SpeciesHomo sapiens (Human)
GeneADRA1D
Synonymalpha1a/d-adrenoceptor
adrenergic receptor delta1
Gpcr8
Adrd1
ADRA1R
[ Show all ]
DiseaseUrinary incontinence
Benign prostatic hyperplasia
Congestive heart failure
Diabetes
Erectile dysfunction
[ Show all ]
Length572
Amino acid sequenceMTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI
UniProtP25100
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseT53381
ChEMBLCHEMBL223
IUPHAR24
DrugBankBE0004863, BE0000715

Ligand

NameCHEMBL41677
Molecular formulaC32H38N2O3
IUPAC namemethyl 1-[3-[[2,2-bis(4-methylphenyl)acetyl]amino]propyl]-4-phenylpiperidine-4-carboxylate
Molecular weight498.667
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP5.8
Synonyms1-[3-(Di-p-tolylacetylamino)propyl]-4-phenylpiperidine-4-carboxylic acid methyl ester
1-[3-(2,2-Di-p-tolyl-acetylamino)-propyl]-4-phenyl-piperidine-4-carboxylic acid methyl ester
BDBM50090304
Inchi KeyBGURRFIDCHOENU-UHFFFAOYSA-N
Inchi IDInChI=1S/C32H38N2O3/c1-24-10-14-26(15-11-24)29(27-16-12-25(2)13-17-27)30(35)33-20-7-21-34-22-18-32(19-23-34,31(36)37-3)28-8-5-4-6-9-28/h4-6,8-17,29H,7,18-23H2,1-3H3,(H,33,35)
PubChem CID44288485
ChEMBLCHEMBL41677
IUPHARN/A
BindingDB50090304
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki960.0 nMPMID10937709BindingDB,ChEMBL
Ki975.0 nMPMID11459670BindingDB,ChEMBL

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