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GPCR

NameD(1B) dopamine receptor
SpeciesHomo sapiens (Human)
GeneDRD5
SynonymGpcr1
DRD1L2
DRD1B
dopamine receptor 5
Dopamine D5 receptor
[ Show all ]
DiseaseSolid tumours
Schizophrenia
Length477
Amino acid sequenceMLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
UniProtP21918
Protein Data BankN/A
GPCR-HGmod modelP21918
3D structure modelThis predicted structure model is from GPCR-EXP P21918.
BioLiPN/A
Therapeutic Target DatabaseT46828
ChEMBLCHEMBL1850
IUPHAR218
DrugBankBE0000145, BE0004889

Ligand

NameS-(-)-Lisuride
Molecular formulaC20H26N4O
IUPAC name3-[(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinolin-9-yl]-1,1-diethylurea
Molecular weight338.455
Hydrogen bond acceptor2
Hydrogen bond donor2
XlogP2.7
Synonyms3,3-diethyl-1-[(4R,7R)-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(15),2,9,12(16),13-pentaen-4-yl]urea
CHEMBL1528238
S(-)-N'-[(8a)-9,10-Didehydro-6-methylergolin-8-yl]-N,N-diethyl-urea
Biomol-NT_000024
EU-0100781
[ Show all ]
Inchi KeyBKRGVLQUQGGVSM-RDTXWAMCSA-N
Inchi IDInChI=1S/C20H26N4O/c1-4-24(5-2)20(25)22-14-10-16-15-7-6-8-17-19(15)13(11-21-17)9-18(16)23(3)12-14/h6-8,10-11,14,18,21H,4-5,9,12H2,1-3H3,(H,22,25)/t14-,18-/m1/s1
PubChem CID11957615
ChEMBLN/A
IUPHARN/A
BindingDB22867
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki3.55 nMPMID12388666BindingDB

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