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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesRattus norvegicus (Rat)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length406
Amino acid sequenceMDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProtQ62758
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4317
IUPHAR9
DrugBankN/A

Ligand

NameCHEMBL61308
Molecular formulaC17H24N4O
IUPAC name1-propan-2-yl-N-(2-pyrrolidin-1-ylethyl)indazole-3-carboxamide
Molecular weight300.406
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP2.4
SynonymsN/A
Inchi KeyBKUHBCKBDMWTFB-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H24N4O/c1-13(2)21-15-8-4-3-7-14(15)16(19-21)17(22)18-9-12-20-10-5-6-11-20/h3-4,7-8,13H,5-6,9-12H2,1-2H3,(H,18,22)
PubChem CID10732996
ChEMBLCHEMBL61308
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Relaxation4.3 %PMID9599243ChEMBL
Relaxation51.0 %PMID9599243ChEMBL

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