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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 2
Species	Homo sapiens (Human)
Gene	MCHR2
Synonym	G-protein coupled receptor 145 melanin-concentrating hormone receptor 2 MCHR-2 MCH2R MCH2 receptor MCH2 G protein-coupled receptor 145 MCH-2R MCH receptor 2 GPRv17 GPR145 MCH-R2 [ Show all ]
Disease	N/A
Length	340
Amino acid sequence	MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProt	Q969V1
Protein Data Bank	N/A
GPCR-HGmod model	Q969V1
3D structure model	This predicted structure model is from GPCR-EXP Q969V1.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5038
IUPHAR	281
DrugBank	N/A

Ligand

Name	CHEMBL197429
Molecular formula	C28H28ClFN4O
IUPAC name	3-(3-chloro-4-fluorophenyl)-1-[[4-(3-cyanophenyl)phenyl]methyl]-1-(3-pyrrolidin-1-ylpropyl)urea
Molecular weight	491.007
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	5.6
Synonyms	BDBM50174828 3-(3-chloro-4-fluoro-phenyl)-1-(3''-cyano-biphenyl-4-ylmethyl)-1-(3-pyrrolidin-1-yl-propyl)-urea
Inchi Key	BPFHLARZSZGTAE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H28ClFN4O/c29-26-18-25(11-12-27(26)30)32-28(35)34(16-4-15-33-13-1-2-14-33)20-21-7-9-23(10-8-21)24-6-3-5-22(17-24)19-31/h3,5-12,17-18H,1-2,4,13-16,20H2,(H,32,35)
PubChem CID	44405421
ChEMBL	CHEMBL197429
IUPHAR	N/A
BindingDB	50174828
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<3000.0 nM	PMID16202583	BindingDB,ChEMBL

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