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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-1A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1a
Synonym	alpha1c alpha1A-adrenoceptor alpha1a Alpha-1C adrenergic receptor Alpha-1A adrenoreceptor Alpha-1A adrenoceptor alpha-1A adrenergic receptor ADRA1C alpha 1C-adrenergic receptor alpha 1A-adrenoreceptor alpha 1A-adrenoceptor adrenergic receptor, alpha 1a adrenergic receptor alpha 1c adrenergic alpha 1c receptor ADRA1L1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
UniProt	P43140
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL319
IUPHAR	22
DrugBank	N/A

Ligand

Name	CHEMBL89380
Molecular formula	C21H34N4O
IUPAC name	2-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]-3,5,6,7,8,8a-hexahydro-1H-imidazo[1,5-a]pyridine
Molecular weight	358.53
Hydrogen bond acceptor	5
Hydrogen bond donor	0
XlogP	3.0
Synonyms	2-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}-octahydro-imidazo[1,5-a]pyridine 2-[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]octahydroimidazo[1,5-a]pyridine BDBM50059468
Inchi Key	BSELYTAEVFSVSK-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H34N4O/c1-26-21-9-3-2-8-20(21)24-15-13-22(14-16-24)10-6-11-23-17-19-7-4-5-12-25(19)18-23/h2-3,8-9,19H,4-7,10-18H2,1H3
PubChem CID	10737133
ChEMBL	CHEMBL89380
IUPHAR	N/A
BindingDB	50059468
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	218.0 nM	PMID9258372	BindingDB,ChEMBL

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