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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	5-hydroxytryptamine receptor 5A
Species	Rattus norvegicus (Rat)
Gene	Htr5a
Synonym	5-HT5A receptor REC17 MR22 Htr5 5-HT-5A 5HT5- 5-HT5A 5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled 5-HT5alpha serotonin receptor 5A [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MDLPINLTSFSLSTPSTLEPNRSLDTEALRTSQSFLSAFRVLVLTLLGFLAAATFTWNLLVLATILRVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRARKRVSNVMILLTWALSAVISLAPLLFGWGETYSELSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYKAAKFRMGSRKTNSVSPIPEAVEVKDASQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDIPALWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ
UniProt	P35364
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4655
IUPHAR	10
DrugBank	N/A

Ligand

Name	CHEMBL263700
Molecular formula	C19H20N2O2
IUPAC name	[3-[2-(dimethylamino)ethyl]-5-hydroxyindol-1-yl]-phenylmethanone
Molecular weight	308.381
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.5
Synonyms	UJELDYRUBKQNKE-UHFFFAOYSA-N BDBM50106252 N,N-Dimethyl-1-benzoyl-5-hydroxy-1H-indole-3-ethanamine [3-(2-Dimethylamino-ethyl)-5-hydroxy-1H-indol-1-yl]phenylmethanone SCHEMBL7443507 [3-(2-Dimethylamino-ethyl)-5-hydroxy-indol-1-yl]-phenyl-methanone [ Show all ]
Inchi Key	UJELDYRUBKQNKE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H20N2O2/c1-20(2)11-10-15-13-21(18-9-8-16(22)12-17(15)18)19(23)14-6-4-3-5-7-14/h3-9,12-13,22H,10-11H2,1-2H3
PubChem CID	9796627
ChEMBL	CHEMBL263700
IUPHAR	N/A
BindingDB	50106252
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	4500.0 nM	PMID11689074	BindingDB,ChEMBL

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