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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesRattus norvegicus (Rat)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length406
Amino acid sequenceMDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProtQ62758
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4317
IUPHAR9
DrugBankN/A

Ligand

NameCHEMBL312898
Molecular formulaC16H21N3O2
IUPAC name4-amino-N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-2,3-dihydro-1-benzofuran-7-carboxamide
Molecular weight287.363
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP1.1
Synonyms2-(4-amino-2,3-dihydrobenzo[b]furan-7-ylcarboxamido)-(2R)-4-azabicyclo[2.2.2]octane
BDBM50288588
Inchi KeyBWZIVCZPLOWYGH-AWEZNQCLSA-N
Inchi IDInChI=1S/C16H21N3O2/c17-13-2-1-12(15-11(13)5-8-21-15)16(20)18-14-9-19-6-3-10(14)4-7-19/h1-2,10,14H,3-9,17H2,(H,18,20)/t14-/m0/s1
PubChem CID44323219
ChEMBLCHEMBL312898
IUPHARN/A
BindingDB50288588
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<1000.0 nM, Bioorg. Med. Chem. Lett., (1996) 6:3:263BindingDB,ChEMBL
Kb<1000.0 nMBioorg. Med. Chem. Lett., (1996) 6:3:263ChEMBL
Ki<1000.0 nM, Bioorg. Med. Chem. Lett., (1996) 6:3:263BindingDB,ChEMBL

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