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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesRattus norvegicus (Rat)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length406
Amino acid sequenceMDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProtQ62758
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4317
IUPHAR9
DrugBankN/A

Ligand

NameCHEMBL293790
Molecular formulaC20H30N4O
IUPAC nameN-(4-piperidin-1-ylbutyl)-1-propan-2-ylindazole-3-carboxamide
Molecular weight342.487
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP3.5
Synonyms1-Isopropyl-N-(4-piperidinobutyl)-1H-indazole-3-carboxamide
Inchi KeyBYSASFQFJKKILP-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H30N4O/c1-16(2)24-18-11-5-4-10-17(18)19(22-24)20(25)21-12-6-9-15-23-13-7-3-8-14-23/h4-5,10-11,16H,3,6-9,12-15H2,1-2H3,(H,21,25)
PubChem CID10593430
ChEMBLCHEMBL293790
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Relaxation3.3 %PMID9599243ChEMBL
Relaxation43.3 %PMID9599243ChEMBL
Relaxation49.0 %PMID9599243ChEMBL

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