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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Neuropeptide Y receptor type 2
Species	Homo sapiens (Human)
Gene	NPY2R
Synonym	NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor
Disease	Diabetes Metabolic disorders Obesity
Length	381
Amino acid sequence	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProt	P49146
Protein Data Bank	N/A
GPCR-HGmod model	P49146
3D structure model	This predicted structure model is from GPCR-EXP P49146.
BioLiP	N/A
Therapeutic Target Database	T10670
ChEMBL	CHEMBL4018
IUPHAR	306
DrugBank	BE0002419

Ligand

Name	MLS000041001
Molecular formula	C17H19N3O
IUPAC name	2-methyl-4-(4-methylpiperidin-1-yl)-[1]benzofuro[3,2-d]pyrimidine
Molecular weight	281.359
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	4.2
Synonyms	HMS2171F15 ZINC4301424 AKOS022125118 2-methyl-4-(4-methylpiperidin-1-yl)[1]benzofuro[3,2-d]pyrimidine CHEMBL1308461 SMR000045843 848741-45-7 HMS3319F12 2-methyl-4-(4-methyl-1-piperidinyl)benzofuro[3,2-d]pyrimidine BDBM42471 MolPort-002-622-592 2-methyl-4-(4-methylpiperidino)benzofuro[3,2-d]pyrimidine cid_664856 STL346108 AC1LDCJA MCULE-6462963070 2-methyl-4-(4-methylpiperidin-1-yl)-[1]benzofuro[3,2-d]pyrimidine REGID_for_CID_664856 [ Show all ]
Inchi Key	AEUVACXSTSXSIX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C17H19N3O/c1-11-7-9-20(10-8-11)17-16-15(18-12(2)19-17)13-5-3-4-6-14(13)21-16/h3-6,11H,7-10H2,1-2H3
PubChem CID	664856
ChEMBL	CHEMBL1308461
IUPHAR	N/A
BindingDB	42471
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	5766.0 nM	PubChem BioAssay data set	ChEMBL

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