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GPCR

NameAlpha-2C adrenergic receptor
SpeciesHomo sapiens (Human)
GeneADRA2C
Synonymalpha2-C4
Adra-2c
ADRA2L2
ADRA2RL2
Adrenergic alpha2C- receptor class I
[ Show all ]
DiseaseDiabetic nephropathy; Fibromyalgia
Hypertension
Heart failure
Glaucoma
Alzheimer disease
[ Show all ]
Length462
Amino acid sequenceMASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
UniProtP18825
Protein Data BankN/A
GPCR-HGmod modelP18825
3D structure modelThis predicted structure model is from GPCR-EXP P18825.
BioLiPN/A
Therapeutic Target DatabaseT01777
ChEMBLCHEMBL1916
IUPHAR27
DrugBankBE0004864, BE0000342, BE0004888

Ligand

NameCHEMBL74283
Molecular formulaC11H14BrN5
IUPAC name5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-1,2,3,4-tetrahydroquinoxalin-6-amine
Molecular weight296.172
Hydrogen bond acceptor3
Hydrogen bond donor4
XlogP1.0
Synonyms6-Quinoxalinamine, 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-1,2,3,4-tetrahydro-
AKOS030558838
5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl-amino)-1,2,3,4-tetrahydro-6-quinoxalinamine
AC1L2ZVH
BDBM50213028
[ Show all ]
Inchi KeyCETMNKCDAHCKRC-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H14BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-2,13-14H,3-6H2,(H2,15,16,17)
PubChem CID131829
ChEMBLCHEMBL74283
IUPHARN/A
BindingDB50213028
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50104.71 nMBioorg. Med. Chem. Lett., (1995) 5:19:2255ChEMBL
EC50105.0 nMN/ABindingDB
Intrinsic activity1.0 -Bioorg. Med. Chem. Lett., (1995) 5:19:2255ChEMBL
Ki213.8 nMBioorg. Med. Chem. Lett., (1995) 5:19:2255ChEMBL
Ki214.0 nMN/ABindingDB

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