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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesHomo sapiens (Human)
GeneMCHR1
SynonymSLC-1
Somatostatin receptor-like protein
MCHR-1
MCHR
MCH1R
[ Show all ]
DiseaseObesity
Obesity; Anxiety; Depression
Length422
Amino acid sequenceMSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProtQ99705
Protein Data BankN/A
GPCR-HGmod modelQ99705
3D structure modelThis predicted structure model is from GPCR-EXP Q99705.
BioLiPN/A
Therapeutic Target DatabaseT09572
ChEMBLCHEMBL344
IUPHAR280
DrugBankBE0003478

Ligand

NameCHEMBL179870
Molecular formulaC25H27N3O2
IUPAC nameN-[4-[3-(dimethylamino)pyrrolidin-1-yl]phenyl]-4-phenoxybenzamide
Molecular weight401.51
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP4.6
SynonymsBDBM50170394
N-[4-(3-Dimethylamino-pyrrolidin-1-yl)-phenyl]-4-phenoxy-benzamide
SCHEMBL12529200
Inchi KeyAAPDSPGBQMKWII-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H27N3O2/c1-27(2)22-16-17-28(18-22)21-12-10-20(11-13-21)26-25(29)19-8-14-24(15-9-19)30-23-6-4-3-5-7-23/h3-15,22H,16-18H2,1-2H3,(H,26,29)
PubChem CID44388308
ChEMBLCHEMBL179870
IUPHARN/A
BindingDB50170394
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID16005225BindingDB,ChEMBL

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