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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(2) dopamine receptor
Species	Mus musculus (Mouse)
Gene	Drd2
Synonym	D2 receptor D2(415) and D₂₍₄₄₄₎ D2A and D_2B D2R dopamine D2 receptor dopamine receptor 2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	444
Amino acid sequence	MDPLNLSWYDDDLERQNWSRPFNGSEGKPDRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProt	P61168
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3427
IUPHAR	215
DrugBank	N/A

Ligand

Name	CHEMBL136205
Molecular formula	C23H29NO2
IUPAC name	1-(cyclopropylmethyl)-4-[[4-(4-methoxyphenyl)phenoxy]methyl]piperidine
Molecular weight	351.49
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.0
Synonyms	1-Cyclopropylmethyl-4-(4''-methoxy-biphenyl-4-yloxymethyl)-piperidine;0.5hydrate BDBM50002276 4-[[[(4'-Methoxy-1,1'-biphenyl)-4-yl]oxy]methyl]-1-(cyclopropylmethyl)piperidine CHEMBL1180644
Inchi Key	DRJKFKHAUSWTAY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H29NO2/c1-25-22-8-4-20(5-9-22)21-6-10-23(11-7-21)26-17-19-12-14-24(15-13-19)16-18-2-3-18/h4-11,18-19H,2-3,12-17H2,1H3
PubChem CID	10383330
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50002276
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	7217.0 nM	PMID1360026	BindingDB

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