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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Alpha-2A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra2a
Synonym	CA2-47 alpha2D alpha2A-AR alpha2A-adrenoceptor alpha2A-adrenergic receptor alpha2A Alpha-2D adrenergic receptor Alpha-2AAR Alpha-2A adrenoreceptor Alpha-2A adrenoceptor adrenergic receptor Adrenergic alpha 2A receptor ADRA2R ADRA2 Adra-2a Adra-2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	450
Amino acid sequence	MGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProt	P22909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL327
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	DEXMEDETOMIDINE
Molecular formula	C13H16N2
IUPAC name	5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole
Molecular weight	200.285
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	3.1
Synonyms	108D583 4-[(s)-1-(2,3-dimethyl-phenyl)-ethyl]-1h-imidazole AK310842 CHEMBL778 Dexdor (TN) Dexmedetomidinum MPV-1440 SW219607-1 1H-Imidazole,5-[(1S)-1-(2,3-dimethylphenyl)ethyl]- API0000529 D00514 Dexmedetomidina [INN-Spanish] GTPL521 RT-012294 UNII-67VB76HONO (+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole AB01566872_02 CHEBI:4466 DB00633 Dexmedetomidine [USAN:INN:BAN] MolPort-035-395-718 SC-78886 113775-47-6 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole AKOS025149503 CTK8E7442 Dexmedetomidin Dexmedetomidinum [INN-Latin] NCGC00025347-01 Tocris-2023 2371AH 67VB76HONO BDBM50085683 D0U3DU KS-00000G0F s3075 UNII-MR15E85MQM component CUHVIMMYOGQXCV-NSHDSACASA-N (S)-5-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-3H-imidazole AC1NSJXT Dexdor DexmedetomidineHclC13H16N2.Hcl MPV 1440 SCHEMBL26433 1H-Imidazole, 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]- AKOS026750524 CUHVIMMYOGQXCV-NSHDSACASA-N Dexmedetomidina FT-0666307 Precedex (TN) TPU 006 (+)-(S)-4-[1-(2,3-dimethylphenyl) ethyl]-1H -imidazole monohydrochloride 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazol AB01566872_01 C07450 Dexmedetomidine (USAN/INN) MCULE-5424054659 SB17478 ZINC4632106 [ Show all ]
Inchi Key	CUHVIMMYOGQXCV-NSHDSACASA-N
Inchi ID	InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1
PubChem CID	5311068
ChEMBL	CHEMBL778
IUPHAR	521
BindingDB	50085683
DrugBank	DB00633
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	0.015 nM	PMID10715142	BindingDB
Ki	0.015 nM	PMID10715142, PMID10753480	BindingDB,ChEMBL
Ki	5.0 nM	PMID10753480	BindingDB,ChEMBL

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