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GPCR

NameC-C chemokine receptor type 10
SpeciesHomo sapiens (Human)
GeneCCR10
SynonymCCR-10
CCR10
CC-CKR-10
G-protein coupled receptor 2
GPR-2
[ Show all ]
DiseaseInflammatory disease
Length362
Amino acid sequenceMGTEATEQVSWGHYSGDEEDAYSAEPLPELCYKADVQAFSRAFQPSVSLTVAALGLAGNGLVLATHLAARRAARSPTSAHLLQLALADLLLALTLPFAAAGALQGWSLGSATCRTISGLYSASFHAGFLFLACISADRYVAIARALPAGPRPSTPGRAHLVSVIVWLLSLLLALPALLFSQDGQREGQRRCRLIFPEGLTQTVKGASAVAQVALGFALPLGVMVACYALLGRTLLAARGPERRRALRVVVALVAAFVVLQLPYSLALLLDTADLLAARERSCPASKRKDVALLVTSGLALARCGLNPVLYAFLGLRFRQDLRRLLRGGSCPSGPQPRRGCPRRPRLSSCSAPTETHSLSWDN
UniProtP46092
Protein Data BankN/A
GPCR-HGmod modelP46092
3D structure modelThis predicted structure model is from GPCR-EXP P46092.
BioLiPN/A
Therapeutic Target DatabaseT71054
ChEMBLCHEMBL2321628
IUPHAR67
DrugBankN/A

Ligand

NameCHEMBL3728616
Molecular formulaC27H28ClFN6O4S
IUPAC name7-(2-chloroanilino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]-N-(2-methoxyethyl)pyrazolo[1,5-a]pyrimidine-3-sulfonamide
Molecular weight587.067
Hydrogen bond acceptor9
Hydrogen bond donor2
XlogP4.0
Synonyms7-(2-chlorophenylamino)-6-[4-(4-fluorophenyl)piperidine-1-carbonyl]-N-(2-methoxyethyl)pyrazolo[1,5-a]pyrimidine-3-sulfonamide
CRXDMRYJOBRNBS-UHFFFAOYSA-N
SCHEMBL14471605
Inchi KeyCRXDMRYJOBRNBS-UHFFFAOYSA-N
Inchi IDInChI=1S/C27H28ClFN6O4S/c1-39-15-12-32-40(37,38)24-17-31-35-25(33-23-5-3-2-4-22(23)28)21(16-30-26(24)35)27(36)34-13-10-19(11-14-34)18-6-8-20(29)9-7-18/h2-9,16-17,19,32-33H,10-15H2,1H3
PubChem CID71178899
ChEMBLCHEMBL3728616
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition28.9 %NoneChEMBL

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