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GPCR

NameD(4) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd4
SynonymD(2C) dopamine receptor
D4 receptor
D4R
Dopamine D4 receptor
dopamine receptor 4
DiseaseN/A for non-human GPCRs
Length387
Amino acid sequenceMGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
UniProtP30729
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3361
IUPHAR217
DrugBankN/A

Ligand

NameCHEMBL3819427
Molecular formulaC20H22N2O2
IUPAC name4-[4-(3,4-dihydro-1H-isoquinolin-2-yl)butanoyl]benzamide
Molecular weight322.408
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP2.3
SynonymsBDBM50182739
SCHEMBL20358377
Inchi KeyHNPAUMYBQXZAJH-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H22N2O2/c21-20(24)17-9-7-16(8-10-17)19(23)6-3-12-22-13-11-15-4-1-2-5-18(15)14-22/h1-2,4-5,7-10H,3,6,11-14H2,(H2,21,24)
PubChem CID127051844
ChEMBLCHEMBL3819427
IUPHARN/A
BindingDB50182739
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki204.0 nMPMID27312422BindingDB
Ki204.17 nMPMID27312422ChEMBL
Ki205.0 nMPMID27312422BindingDB,ChEMBL

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