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GPCR

NameD(2) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd2
SynonymD2 receptor
D2(415) and D2(444)
D2A and D2B
D2R
Dopamine D2 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
UniProtP61169
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL339
IUPHAR215
DrugBankN/A

Ligand

NameCHEMBL314226
Molecular formulaC15H17FN6
IUPAC name7-fluoro-2-methyl-4-piperazin-1-yl-10H-pyrazolo[3,4-b][1,5]benzodiazepine
Molecular weight300.341
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP1.6
SynonymsAATNUAIEJXUQIC-UHFFFAOYSA-N
7-fluoro-2,10-dihydro-2-methyl-4-(1-piperazinyl)pyrazolo[3,4-b][1,5]benzodiazepine
BDBM50017640
2-Methyl-4-(piperazin-1-yl)-7-fluoro-2,10-dihydropyrazolo[3,4-b][1,5]benzodiazepine
SCHEMBL10982149
[ Show all ]
Inchi KeyAATNUAIEJXUQIC-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H17FN6/c1-21-9-11-14(20-21)18-12-3-2-10(16)8-13(12)19-15(11)22-6-4-17-5-7-22/h2-3,8-9,17H,4-7H2,1H3,(H,18,20)
PubChem CID135759115
ChEMBLCHEMBL314226
IUPHARN/A
BindingDB50017640
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC505200.0 nMPMID2573732BindingDB,ChEMBL

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