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GPCR

NameD(4) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd4
SynonymD(2C) dopamine receptor
D4 receptor
D4R
Dopamine D4 receptor
dopamine receptor 4
DiseaseN/A for non-human GPCRs
Length387
Amino acid sequenceMGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
UniProtP30729
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3361
IUPHAR217
DrugBankN/A

Ligand

NameCHEMBL3924565
Molecular formulaC20H23Cl2NO
IUPAC name1-(4-chlorophenyl)-4-(1,3,4,5-tetrahydro-2-benzazepin-2-yl)butan-1-one;hydrochloride
Molecular weight364.31
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogPNone
SynonymsSCHEMBL20359518
BDBM50199128
Inchi KeyFPDLYMXLPOEFDP-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H22ClNO.ClH/c21-19-11-9-17(10-12-19)20(23)8-4-14-22-13-3-7-16-5-1-2-6-18(16)15-22;/h1-2,5-6,9-12H,3-4,7-8,13-15H2;1H
PubChem CID134141354
ChEMBLCHEMBL3924565
IUPHARN/A
BindingDB50199128
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Ki442.0 nMPMID27717652BindingDB,ChEMBL
Ki446.68 nMPMID27717652ChEMBL
Ki447.0 nMPMID27717652BindingDB

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