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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Homo sapiens (Human)
Gene	MCHR1
Synonym	SLC-1 Somatostatin receptor-like protein MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 [ Show all ]
Disease	Obesity Obesity; Anxiety; Depression
Length	422
Amino acid sequence	MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARLWEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESKGT
UniProt	Q99705
Protein Data Bank	N/A
GPCR-HGmod model	Q99705
3D structure model	This predicted structure model is from GPCR-EXP Q99705.
BioLiP	N/A
Therapeutic Target Database	T09572
ChEMBL	CHEMBL344
IUPHAR	280
DrugBank	BE0003478

Ligand

Name	CHEMBL1914639
Molecular formula	C28H36ClN3O2
IUPAC name	7-[4-[4-(4-chlorophenyl)piperidin-1-yl]butanoyl]-N-ethyl-1,2,4,5-tetrahydro-3-benzazepine-3-carboxamide
Molecular weight	482.065
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	4.8
Synonyms	BDBM50357510
Inchi Key	AHHLDXACAMZJFP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H36ClN3O2/c1-2-30-28(34)32-18-13-22-5-6-25(20-24(22)14-19-32)27(33)4-3-15-31-16-11-23(12-17-31)21-7-9-26(29)10-8-21/h5-10,20,23H,2-4,11-19H2,1H3,(H,30,34)
PubChem CID	57401510
ChEMBL	CHEMBL1914639
IUPHAR	N/A
BindingDB	50357510
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	8.1 nM	PMID21975069	BindingDB,ChEMBL

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