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GPCR

Name	Neuropeptide Y receptor type 2
Species	Homo sapiens (Human)
Gene	NPY2R
Synonym	NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor
Disease	Diabetes Metabolic disorders Obesity
Length	381
Amino acid sequence	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProt	P49146
Protein Data Bank	N/A
GPCR-HGmod model	P49146
3D structure model	This predicted structure model is from GPCR-EXP P49146.
BioLiP	N/A
Therapeutic Target Database	T10670
ChEMBL	CHEMBL4018
IUPHAR	306
DrugBank	BE0002419

Ligand

Name	MLS000760186
Molecular formula	C18H19ClN2O3S
IUPAC name	[4-(2-chlorophenyl)piperazin-1-yl]-(3,4-dihydroxy-5-methoxyphenyl)methanethione
Molecular weight	378.871
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	3.5
Synonyms	CHEMBL1386851 Z57052919 (4Z)-4-[[4-(2-chlorophenyl)piperazin-1-yl]-sulfanyl-methylidene]-2-methoxy-6-oxidanyl-cyclohexa-2,5-dien-1-one AC1O1JMF MCULE-9607151367 4-[[4-(2-chlorophenyl)piperazin-1-yl]-sulfanylmethylidene]-2-hydroxy-6-methoxycyclohexa-2,5-dien-1-one BDBM61839 SCHEMBL12950710 (4E)-4-[[4-(2-chlorophenyl)piperazin-1-yl]-sulfanylmethylidene]-2-hydroxy-6-methoxycyclohexa-2,5-dien-1-one 796067-84-0 cid_6098163 ZINC03338785 (4Z)-4-[[4-(2-chlorophenyl)piperazin-1-yl]-sulfanylmethylidene]-2-hydroxy-6-methoxycyclohexa-2,5-dien-1-one AC1O9DOH 5-[4-(2-chlorophenyl)piperazine-1-carbothioyl]-3-methoxybenzene-1,2-diol SMR000368614 (4Z)-4-[[4-(2-chlorophenyl)-1-piperazinyl]-mercaptomethylidene]-2-hydroxy-6-methoxy-1-cyclohexa-2,5-dienone AC1NWIA4 HMS2697P21 ZINC13121809 (4Z)-4-[[4-(2-chlorophenyl)piperazino]-mercapto-methylene]-2-hydroxy-6-methoxy-cyclohexa-2,5-dien-1-one AKOS034471830 MolPort-004-281-658 [ Show all ]
Inchi Key	BUROKOGOWXVRCQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H19ClN2O3S/c1-24-16-11-12(10-15(22)17(16)23)18(25)21-8-6-20(7-9-21)14-5-3-2-4-13(14)19/h2-5,10-11,22-23H,6-9H2,1H3
PubChem CID	2455058
ChEMBL	CHEMBL1386851
IUPHAR	N/A
BindingDB	61839
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	<35430.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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