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GPCR

NameD(2) dopamine receptor
SpeciesBos taurus (Bovine)
GeneDRD2
SynonymDopamine D2 receptor
DiseaseN/A for non-human GPCRs
Length444
Amino acid sequenceMDPLNLSWYDDDPESRNWSRPFNGSEGKADRPPYNYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPMLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRANLKAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKTVNPKIAKIFEIQSMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProtP20288
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3998
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL268558
Molecular formulaC22H21ClN4
IUPAC name1-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]pyrazolo[5,1-a]isoquinoline
Molecular weight376.888
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP4.4
Synonyms1-[[4-(4-Chlorophenyl)piperazine-1-yl]methyl]pyrazolo[5,1-a]isoquinoline
BDBM50073802
4-(4-Chloro-phenyl)-1-pyrazolo[5,1-a]isoquinolin-1-ylmethyl-piperazin-1-ium
1-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-pyrazolo[5,1-a]isoquinoline
Inchi KeyDUEAFIKCLDPEGV-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H21ClN4/c23-19-5-7-20(8-6-19)26-13-11-25(12-14-26)16-18-15-24-27-10-9-17-3-1-2-4-21(17)22(18)27/h1-10,15H,11-14,16H2
PubChem CID44263882
ChEMBLCHEMBL268558
IUPHARN/A
BindingDB50073802
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<100000.0 nMPMID9990464BindingDB,ChEMBL

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