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GPCR

NameD(4) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd4
SynonymD(2C) dopamine receptor
D4 receptor
D4R
Dopamine D4 receptor
dopamine receptor 4
DiseaseN/A for non-human GPCRs
Length387
Amino acid sequenceMGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
UniProtP30729
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3361
IUPHAR217
DrugBankN/A

Ligand

NameCHEMBL190821
Molecular formulaC31H38N4O2
IUPAC nameN-[1-[2-[(4aR)-8-methoxy-1,2,4,4a,5,6-hexahydropyrazino[1,2-a]quinolin-3-yl]ethyl]piperidin-4-yl]naphthalene-2-carboxamide
Molecular weight498.671
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP5.1
SynonymsBDBM50166020
Naphthalene-2-carboxylic acid {1-[2-((R)-8-methoxy-1,2,4,4a,5,6-hexahydro-pyrazino[1,2-a]quinolin-3-yl)-ethyl]-piperidin-4-yl}-amide
Inchi KeyDVXDATODDZJCOX-MUUNZHRXSA-N
Inchi IDInChI=1S/C31H38N4O2/c1-37-29-10-11-30-25(21-29)8-9-28-22-34(18-19-35(28)30)17-16-33-14-12-27(13-15-33)32-31(36)26-7-6-23-4-2-3-5-24(23)20-26/h2-7,10-11,20-21,27-28H,8-9,12-19,22H2,1H3,(H,32,36)/t28-/m1/s1
PubChem CID11375449
ChEMBLCHEMBL190821
IUPHARN/A
BindingDB50166020
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki<50000.0 nMPMID15857123BindingDB,ChEMBL

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