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GPCR

NameMelanin-concentrating hormone receptor 2
SpeciesHomo sapiens (Human)
GeneMCHR2
SynonymG-protein coupled receptor 145
melanin-concentrating hormone receptor 2
MCHR-2
MCH2R
MCH2 receptor
[ Show all ]
DiseaseN/A
Length340
Amino acid sequenceMNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
UniProtQ969V1
Protein Data BankN/A
GPCR-HGmod modelQ969V1
3D structure modelThis predicted structure model is from GPCR-EXP Q969V1.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5038
IUPHAR281
DrugBankN/A

Ligand

NameCHEMBL211504
Molecular formulaC30H31Cl3FN3O
IUPAC nameN-(3-chloro-4-fluorophenyl)-2-[[1-cyclopentyl-4-[4-(3,5-dichlorophenyl)phenyl]piperidin-4-yl]amino]acetamide
Molecular weight574.946
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP7.5
SynonymsBDBM50186780
N-(3-chloro-4-fluoro-phenyl)-2-[1-cyclopentyl-4-(3'',5''-dichloro-biphenyl-4-yl)-piperidin-4-ylamino]-acetamide
Inchi KeyDXZCQJLJSTXNQD-UHFFFAOYSA-N
Inchi IDInChI=1S/C30H31Cl3FN3O/c31-23-15-21(16-24(32)17-23)20-5-7-22(8-6-20)30(11-13-37(14-12-30)26-3-1-2-4-26)35-19-29(38)36-25-9-10-28(34)27(33)18-25/h5-10,15-18,26,35H,1-4,11-14,19H2,(H,36,38)
PubChem CID10239930
ChEMBLCHEMBL211504
IUPHARN/A
BindingDB50186780
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki<3000.0 nMPMID16690312BindingDB,ChEMBL

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