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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesRattus norvegicus (Rat)
GeneHtr4
Synonym5-HT-4
5-HT4
5-HT4 receptor
5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length406
Amino acid sequenceMDRLDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVNAFGAIELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRPQTADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEKVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRDTVECGGQWESRCHLTATSPLVAAQPVIRRPQDNDLEDSCSLKRSQS
UniProtQ62758
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4317
IUPHAR9
DrugBankN/A

Ligand

NameCHEMBL301680
Molecular formulaC25H31FN6O2
IUPAC nameN-[2-[4-[(4-fluorophenyl)carbamoylamino]piperidin-1-yl]ethyl]-1-propan-2-ylindazole-3-carboxamide
Molecular weight466.561
Hydrogen bond acceptor5
Hydrogen bond donor3
XlogP3.3
SynonymsN/A
Inchi KeyDYNTUEJKWRKFJT-UHFFFAOYSA-N
Inchi IDInChI=1S/C25H31FN6O2/c1-17(2)32-22-6-4-3-5-21(22)23(30-32)24(33)27-13-16-31-14-11-20(12-15-31)29-25(34)28-19-9-7-18(26)8-10-19/h3-10,17,20H,11-16H2,1-2H3,(H,27,33)(H2,28,29,34)
PubChem CID10552169
ChEMBLCHEMBL301680
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Relaxation6.3 %PMID9599243ChEMBL
Relaxation44.8 %PMID9599243ChEMBL
Relaxation45.5 %PMID9599243ChEMBL

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