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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2C
Species	Rattus norvegicus (Rat)
Gene	Htr2c
Synonym	5-HT-1C serotonin 1c receptor HTR1C 5-hydroxytryptamine receptor 1C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-HTR2C 5-HT2C receptor 5-HT2C 5-HT1C 5-HT-2C serotonin receptor 2C [ Show all ]
Disease	N/A for non-human GPCRs
Length	460
Amino acid sequence	MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
UniProt	P08909
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL324
IUPHAR	8
DrugBank	BE0004882

Ligand

Name	CHEMBL3261700
Molecular formula	C28H29N3O2
IUPAC name	1-[3-[3-(dimethylamino)-1-phenylpropoxy]phenyl]-3-naphthalen-2-ylurea
Molecular weight	439.559
Hydrogen bond acceptor	3
Hydrogen bond donor	2
XlogP	5.6
Synonyms	BDBM50013057
Inchi Key	ALDRIQSARZMVEV-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H29N3O2/c1-31(2)18-17-27(22-10-4-3-5-11-22)33-26-14-8-13-24(20-26)29-28(32)30-25-16-15-21-9-6-7-12-23(21)19-25/h3-16,19-20,27H,17-18H2,1-2H3,(H2,29,30,32)
PubChem CID	90656239
ChEMBL	CHEMBL3261700
IUPHAR	N/A
BindingDB	50013057
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	87.6 nM	PMID24717153	ChEMBL
Ki	88.0 nM	PMID24717153	BindingDB

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