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GPCR

NameC-X-C chemokine receptor type 2
SpeciesHomo sapiens (Human)
GeneCXCR2
Synonymchemokine (C-X-C motif) receptor 2
KC receptor
CD128
IL8RB
IL-8R2
[ Show all ]
DiseaseCystic fibrosis; Chronic obstructive pulmonary disease
Asthma
Cancer
Ischemia-reperfusion injury; Lung transplantation; Graft rejection in heart transplantation
Fungal infections
[ Show all ]
Length360
Amino acid sequenceMEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
UniProtP25025
Protein Data BankN/A
GPCR-HGmod modelP25025
3D structure modelThis predicted structure model is from GPCR-EXP P25025.
BioLiPN/A
Therapeutic Target DatabaseT56923
ChEMBLCHEMBL2434
IUPHAR69
DrugBankN/A

Ligand

NameCHEMBL254981
Molecular formulaC24H23F4N3O4
IUPAC name3-[[2-[[(1R)-1-[3-fluoro-5-(trifluoromethyl)phenyl]-2-methylpropyl]amino]-3,4-dioxocyclobuten-1-yl]amino]-2-hydroxy-N,N-dimethylbenzamide
Molecular weight493.459
Hydrogen bond acceptor10
Hydrogen bond donor3
XlogP5.0
SynonymsBDBM50236054
(R)-3-(2-(1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-methylpropylamino)-3,4-dioxocyclobut-1-enylamino)-2-hydroxy-N,N-dimethylbenzamide
Inchi KeyALECVXATYUKGSG-QGZVFWFLSA-N
Inchi IDInChI=1S/C24H23F4N3O4/c1-11(2)17(12-8-13(24(26,27)28)10-14(25)9-12)30-19-18(21(33)22(19)34)29-16-7-5-6-15(20(16)32)23(35)31(3)4/h5-11,17,29-30,32H,1-4H3/t17-/m1/s1
PubChem CID44447963
ChEMBLCHEMBL254981
IUPHARN/A
BindingDB50236054
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki13.0 nMPMID18304809BindingDB
Ki13.3 nMPMID18304809ChEMBL

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