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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Mus musculus (Mouse)
Gene	Htr2a
Synonym	serotonin 5HT-2 receptor 5Ht-2 'D' receptor 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 5-HT2A receptor 5-HT-2A 5-HT-2 Serotonin receptor 2A [ Show all ]
Disease	N/A for non-human GPCRs
Length	471
Amino acid sequence	MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
UniProt	P35363
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5377
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	SMR000060793
Molecular formula	C23H31N3O6S
IUPAC name	2-[4-[2-hydroxy-3-(4-morpholin-4-ylsulfonylphenoxy)propyl]piperazin-1-yl]phenol
Molecular weight	477.576
Hydrogen bond acceptor	9
Hydrogen bond donor	2
XlogP	1.3
Synonyms	CHEMBL1350084 716375-94-9 MLS000054455 AKOS034456039 2-(4-{2-hydroxy-3-[4-(morpholine-4-sulfonyl)phenoxy]propyl}piperazin-1-yl)phenol HMS2493G22 AB00425576-09 MLS000879856 Z56798524 2-[4-[2-hydroxy-3-(4-morpholin-4-ylsulfonylphenoxy)propyl]piperazin-1-yl]phenol MCULE-4697345090 AC1MHC2Q MolPort-004-247-305 [ Show all ]
Inchi Key	FNAQITQLNSNPNB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C23H31N3O6S/c27-19(17-24-9-11-25(12-10-24)22-3-1-2-4-23(22)28)18-32-20-5-7-21(8-6-20)33(29,30)26-13-15-31-16-14-26/h1-8,19,27-28H,9-18H2
PubChem CID	2999575
ChEMBL	CHEMBL1350084
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	76078.0 nM	PubChem BioAssay data set	ChEMBL

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