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GPCR

Name5-hydroxytryptamine receptor 1A
SpeciesRattus norvegicus (Rat)
GeneHtr1a
Synonym5-HT1A receptor
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
5-HT1A
ADRB2RL1
ADRBRL1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length422
Amino acid sequenceMDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProtP19327
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL273
IUPHAR1
DrugBankN/A

Ligand

NameCHEMBL540064
Molecular formulaC28H40ClFN2O3
IUPAC name8-[4-[[(2S)-8-acetyl-5-fluoro-1,2,3,4-tetrahydronaphthalen-2-yl]-propylamino]butyl]-8-azaspiro[4.5]decane-7,9-dione;hydrochloride
Molecular weight507.087
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogPNone
SynonymsN/A
Inchi KeyABISYNUPIBFUQK-BOXHHOBZSA-N
Inchi IDInChI=1S/C28H39FN2O3.ClH/c1-3-14-30(21-8-9-23-24(17-21)22(20(2)32)10-11-25(23)29)15-6-7-16-31-26(33)18-28(19-27(31)34)12-4-5-13-28;/h10-11,21H,3-9,12-19H2,1-2H3;1H/t21-;/m0./s1
PubChem CID45265083
ChEMBLCHEMBL540064
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition70.0 %PMID8831769ChEMBL
Inhibition91.0 %PMID8831769ChEMBL
Inhibition93.0 %PMID8831769ChEMBL
Inhibition97.0 %PMID8831769ChEMBL
Inhibition102.0 %PMID8831769ChEMBL
Inhibition104.0 %PMID8831769ChEMBL
Inhibition109.0 %PMID8831769ChEMBL
Ki13.9 nMPMID8831769ChEMBL

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