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GLASS

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GPCR

Name	5-hydroxytryptamine receptor 6
Species	Homo sapiens (Human)
Gene	HTR6
Synonym	5-HT6 receptor 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 5-HT-6 serotonin receptor 6 ST-B17 5-HT6 [ Show all ]
Disease	Schizophrenia Obesity Neurological disease Neurodegenerative disease Emesis Cognitive disorders Unspecified Anxiety disorder Alzheimer disease; Dementia Alzheimer disease; Anxiety disorder Alzheimer disease [ Show all ]
Length	440
Amino acid sequence	MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNTSNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLISLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQCRLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVPRTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPGLFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGPRPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNFFNIDPAEPELRPHPLGIPTN
UniProt	P50406
Protein Data Bank	N/A
GPCR-HGmod model	P50406
3D structure model	This predicted structure model is from GPCR-EXP P50406.
BioLiP	N/A
Therapeutic Target Database	T16691
ChEMBL	CHEMBL3371
IUPHAR	11
DrugBank	BE0000945

Ligand

Name	tolylpiperidine, 9g
Molecular formula	C18H22N2O
IUPAC name	3-[(2-methyl-3-piperidin-4-ylphenoxy)methyl]pyridine
Molecular weight	282.387
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	2.8
Synonyms	3-[2-methyl-3-(piperidin-4-yl)phenoxymethyl]pyridine CHEMBL449581 BDBM28600
Inchi Key	ANXSUZBBWPTUDU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H22N2O/c1-14-17(16-7-10-19-11-8-16)5-2-6-18(14)21-13-15-4-3-9-20-12-15/h2-6,9,12,16,19H,7-8,10-11,13H2,1H3
PubChem CID	25263319
ChEMBL	CHEMBL449581
IUPHAR	N/A
BindingDB	28600
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	<440.0 nM	PMID19346128	BindingDB,ChEMBL

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