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GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	AM251
Molecular formula	C22H21Cl2IN4O
IUPAC name	1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide
Molecular weight	555.241
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	6.5
Synonyms	KBio2_005381 MFCD01861181 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide NC00374 4CA-0138 SB19550 AM251, >98% (HPLC), solid UNII-3I4FA44MAI Bio1_000608 BSPBio_001525 CHEMBL285932 FT-0661538 HMS3402M07 KBioGR_000245 MolPort-003-983-507 1H-Pyrazole-3-carboxamide,1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl- NCGC00025011-03 AKOS024456393 SR-01000597360 BC600320 Bio2_000725 C22H21Cl2IN4O CTK8E9265 HMS1791M07 HY-15443 KBio2_000245 L000964 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide s2819 AM-251 SW197754-2 BDBM21279 BRD-K92000912-001-02-7 CHEBI:90724 DTXSID7042695 HMS3267K22 KBio3_000489 MLS000758233 183232-66-8 NCGC00025011-01 AC1L1CZ3 SCHEMBL1040316 AM251/AM-251 ZINC1997139 Bio1_001097 BUZAJRPLUGXRAB-UHFFFAOYSA-N CPD000466284 GTPL3317 HMS3649G04 KBioSS_000245 N-(piperidin-1-yl)-1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide NCGC00025011-04 AM 251 SR-01000597360-1 BCP21728 BML3-F08 CBiol_001833 D08YQT HMS1989M07 IDI1_033995 KBio2_002813 LS-184236 1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide N-Piperidino-1-(2,4-dichlorophenyl)-4-methyl-5-(4-iodophenyl)-1H-pyrazole-3-carboxamide 3I4FA44MAI SAM001247081 Tocris-1117 Bio1_000119 BRD-K92000912-001-06-8 EX-A696 HMS3394K15 KBio3_000490 MLS001424171 1h-pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-n-1-piperidinyl- NCGC00025011-02 AC1Q5Q3V SMR000466284 AOB33718 Bio2_000245 C20220 CS-3920 HMS1361M07 HMS3651B15 J-011727 KS-0000180H 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(1-piperidyl)pyrazole-3-carboxamide N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide 2208AH RT-011260 AM 251 (pharmaceutical) SR-01000597360-6 BCP9000280 BN0063 CCG-101124 DB-004430 HMS2052K15 [ Show all ]
Inchi Key	BUZAJRPLUGXRAB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)
PubChem CID	2125
ChEMBL	CHEMBL285932
IUPHAR	3317
BindingDB	21279
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
33464	Cannabinoid receptor 1	P21554	CNR1	Homo sapiens (Human)	472
33465	Cannabinoid receptor 1	P20272	Cnr1	Rattus norvegicus (Rat)	473
33467	Cannabinoid receptor 2	P47936	Cnr2	Mus musculus (Mouse)	347
33468	Cannabinoid receptor 2	P34972	CNR2	Homo sapiens (Human)	360
33466	G-protein coupled receptor 55	Q9Y2T6	GPR55	Homo sapiens (Human)	319
553420	N-arachidonyl glycine receptor	Q14330	GPR18	Homo sapiens (Human)	331
33463	Neuropeptide S receptor	Q6W5P4	NPSR1	Homo sapiens (Human)	371

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