Zhang Lab

University of Michigan

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Check the ligand table for details.
Go to the GPCR list to see GPCRs with which this ligand interacts.
Go to the individual GPCR page for PubMed ID information by text mining.
Download a TSV version of all interaction data.
Go back to previous page.

Ligand

Name	Zacopride
Molecular formula	C15H20ClN3O2
IUPAC name	4-amino-N-(1-azabicyclo[2.2.2]octan-3-yl)-5-chloro-2-methoxybenzamide
Molecular weight	309.794
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	1.7
Synonyms	L001315 Zacoprida Zacopridum [Latin] (RS)-Zacopride 4-amino-N-(1-azabicyclo(2,2,2)oct-3-yl)-5-chloro-2-methoxybenzamide-2-butenedioate 90182-92-6 CHEBI:91810 DTXSID1048251 PDSP1_001704 Zacopride [INN] 4-amino-N-(1-azabicyclo[2.2.2]octan-8-yl)-5-chloro-2-methoxybenzamide BDBM50000492 HTR5A4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-benzamide Racemic zacopride ZACOPRIDE,S 4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-benzamide (Zacopride) 4-AMINO-N-1-AZABICYCLO[2.2.2]OCT-3-YL-5-CHLORO-2-METHOXYBENZAMIDE HYDROCHLORIDE BRD-A65615053-311-05-2 LS-178113 Zacoprida [Spanish] (zacopride)4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-benzamide 4-amino-n-(1-azabicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxybenzamide AC1L33HT FEROPKNOYKURCJ-UHFFFAOYSA-N PDSP2_001600 ZACOPRIDE,R 4-amino-5-iodo-2-methoxy-N-(1-azabicyclo(2.2.2)oct-3-yl)benzamide 4-Amino-N-1-azabicyclo(2.2.2)oct-3-yl-5-chloro-2-methoxybenzamide Benzamide, 4-amino-N-1-azabicyclo(2.2.2)oct-3-yl-5-chloro-2-methoxy- iodozacopride SCHEMBL16003 Zacopridum (.+/-.)-Zacopride 4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-benzamide(zacopride) C15H20ClN3O2 PDSP1_001616 4-amino-N-(1-azabicyclo[2.2.2]octan-3-yl)-5-chloro-2-methoxybenzamide AC1Q3LTX CHEMBL18041 GTPL245 PDSP2_001687 ZACOPRIDE,RS 4-Amino-N-(1-aza-bicyclo[2.2.2]oct-3-yl)-5-chloro-2-methoxy-benzamide 4-amino-n-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamide BRD-A65615053-003-01-4 [ Show all ]
Inchi Key	FEROPKNOYKURCJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C15H20ClN3O2/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20)
PubChem CID	108182
ChEMBL	CHEMBL18041
IUPHAR	245
BindingDB	50000492
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Known GPCRs

You can:

Click GLASS IDs to check the association information.
Click protein names to check details of the GPCRs.
Download a TSV version of all interaction information.

GLASS ID	Name	UniProt	Gene	Species	Length
76575	5-hydroxytryptamine receptor 1B	P28222	HTR1B	Homo sapiens (Human)	390
76566	5-hydroxytryptamine receptor 1D	P28221	HTR1D	Homo sapiens (Human)	377
76576	5-hydroxytryptamine receptor 1E	P28566	HTR1E	Homo sapiens (Human)	365
76572	5-hydroxytryptamine receptor 1F	P30939	HTR1F	Homo sapiens (Human)	366
76579	5-hydroxytryptamine receptor 2A	P28223	HTR2A	Homo sapiens (Human)	471
555766	5-hydroxytryptamine receptor 2A	P14842	Htr2a	Rattus norvegicus (Rat)	471
76568	5-hydroxytryptamine receptor 2B	P41595	HTR2B	Homo sapiens (Human)	481
76567	5-hydroxytryptamine receptor 2C	P28335	HTR2C	Homo sapiens (Human)	458
76580	5-hydroxytryptamine receptor 2C	P08909	Htr2c	Rattus norvegicus (Rat)	460
76570	5-hydroxytryptamine receptor 4	Q13639	HTR4	Homo sapiens (Human)	388
76571	5-hydroxytryptamine receptor 4	Q62758	Htr4	Rattus norvegicus (Rat)	406
76574	5-hydroxytryptamine receptor 4	O70528	HTR4	Cavia porcellus (Guinea pig)	388
553651	5-hydroxytryptamine receptor 4	P97288	Htr4	Mus musculus (Mouse)	388
76573	5-hydroxytryptamine receptor 5A	P47898	HTR5A	Homo sapiens (Human)	357
76577	5-hydroxytryptamine receptor 5A	P35364	Htr5a	Rattus norvegicus (Rat)	357
76565	5-hydroxytryptamine receptor 5B	P35365	Htr5b	Rattus norvegicus (Rat)	370
76578	5-hydroxytryptamine receptor 7	P34969	HTR7	Homo sapiens (Human)	479
555767	5-hydroxytryptamine receptor 7	P32305	Htr7	Rattus norvegicus (Rat)	448

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218