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BindProfX standalone program
- Non-redundant mutation dataset.
Experimentally measured free energy change (ΔΔG) upon interface residue mutation, collected
from the SKEMPI database.
This benchmark set contains 1,402 entries for 116 protein complexes used for benchmarking
BindProfX program, where 1,131 entries are single-point mutations, 195 are double-points mutations,
and 76 are three or higher-order mutations.
The interface residues are classified as RIM (partially buried upon binding), COR (mostly exposed
prior to binding and fully buried in complex), and SUP (mostly buried prior to binding and fully
buried in complex).
- Excel format ΔΔG predicted by BindProfX interface profile, FoldX, Dcomplex2, and BeAtMuSiC.
- Reconstructed dimer structures from ZEMu dataset.
- Peng Xiong, Chengxin Zhang, Wei Zheng, Yang Zhang.
BindProfX: Assessing mutation-induced binding affinity change by protein interface profiles with pseudo counts.
Journal of Molecular Biology, 429: 426-434, 2017.