Structure of PDB 2uue Chain D

Receptor sequence

>2uueD (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]

VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAILVDWLVEVGEE
YKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPE
VAEFVYITDDTYTKKQVLRMEHLVLKVLTFDLAAPTVNQFLTQYFLHQQP
ANCKVESLAMFLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE
SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYKNSKYHGVSLL
NPPETLNL

3D structure

PDB

2uue Replace: A Strategy for Iterative Design of Cyclin- Binding Groove Inhibitors

Chain

Resolution

2.06 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	D	M210 I213 L214 W217 R250 Q254 T282 D283 T285	M36 I39 L40 W43 R76 Q80 T108 D109 T111
BS02	GVC	D	W217 E220 V221 Q254 I281 T282	W43 E46 V47 Q80 I107 T108

Gene Ontology

	Molecular Function
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity

	Biological Process
GO:0044772	mitotic cell cycle phase transition

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:2uue, PDBe:2uue, PDBj:2uue
PDBsum	2uue
PubMed	17051658
UniProt	P20248\|CCNA2_HUMAN Cyclin-A2 (Gene Name=CCNA2)

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