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TM-score TM-align MM-align RNA-align NW-align LS-align EDTSurf MVP MVP-Fit SPICKER HAAD PSSpred 3DRobot MR-REX I-TASSER-MR SVMSEQ NeBcon ResPRE TripletRes WDL-RF ATPbind DockRMSD DeepMSA FASPR EM-Refiner

BioLiP E. coli GLASS GPCR-HGmod GPCR-RD GPCR-EXP Tara-3D TM-fold DECOYS POTENTIAL RW/RWplus EvoEF HPSF THE-DB ADDRESS Alpaca-Antibody CASP7 CASP8 CASP9 CASP10 CASP11 CASP12 CASP13 CASP14

C-QUARK logo

C-QUARK (stands for 'Contact-assisted QUARK') is a new method for ab initio protein structure prediction. As the name indicates, C-QUARK is extended from QUARK but significantly outperforms the latter by the integration of deep-learning based contact-map predictions into the fragment assembly simulations. C-QUARK contains three consecutive steps: First, multiple contact-maps are predicted by ResPRE and NeBcon. Second, QUARK-based replica-exchange Monte Carlo (REMC) folding simulations are performed under the guidance of a new 3-gradient contact potential. Finally, structural conformations generated in the REMC simulations are submitted to SPICKER for decoy selection, with final atomic models constructed and refined by ModRefiner and FASPR. C-QUARK participated (as 'QUARK') in the most recent community-wide CASP13 and CASP14 and was ranked one of the best server methods for ab initio (or template-free modeling, FM) structure prediction in the experiments. File format of prediction results can be found at the Help Page. For more questions, please post them at our Discussion Board.


C-QUARK On-Line (View an example of C-QUARK output)


C-QUARK Resource:
C-QUARK Download:

References:

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