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GPCR

NameProbable G-protein coupled receptor 142
SpeciesHomo sapiens (Human)
GeneGPR142
SynonymAXOR103
G-protein coupled receptor PGR2
GPR142
KIF19
DiseaseN/A
Length462
Amino acid sequenceMSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
UniProtQ7Z601
Protein Data BankN/A
GPCR-HGmod modelQ7Z601
3D structure modelThis predicted structure model is from GPCR-EXP Q7Z601.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2069161
IUPHAR132
DrugBankN/A

Ligand

NameCHEMBL2409023
Molecular formulaC21H28N8O2
IUPAC name5-(ethoxymethyl)-N-[(3-methylimidazol-4-yl)methyl]-1-(5-methyl-4-pyrrolidin-1-ylpyrimidin-2-yl)pyrazole-4-carboxamide
Molecular weight424.509
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP0.8
SynonymsSCHEMBL2390061
BDBM50437414
Inchi KeyGPECVAUSDZMJAZ-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H28N8O2/c1-4-31-13-18-17(20(30)23-11-16-10-22-14-27(16)3)12-25-29(18)21-24-9-15(2)19(26-21)28-7-5-6-8-28/h9-10,12,14H,4-8,11,13H2,1-3H3,(H,23,30)
PubChem CID67389603
ChEMBLCHEMBL2409023
IUPHARN/A
BindingDB50437414
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5014.0 nMPMID24900747BindingDB,ChEMBL

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