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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucose-dependent insulinotropic receptor
Species	Mus musculus (Mouse)
Gene	Gpr119
Synonym	G protein-coupled receptor 119 G-protein coupled receptor 119 G-protein coupled receptor 2 glucose-dependent insulinotropic receptor GPCR2 GPR119 [ Show all ]
Disease	N/A for non-human GPCRs
Length	335
Amino acid sequence	MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRESAYHIVTISHPELDG
UniProt	Q7TQP3
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5263
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL2086668
Molecular formula	C21H35N5O5S
IUPAC name	tert-butyl (3R)-3-methyl-4-[5-[(1-methylsulfonylpiperidin-4-yl)methoxy]pyrimidin-2-yl]piperazine-1-carboxylate
Molecular weight	469.601
Hydrogen bond acceptor	9
Hydrogen bond donor	0
XlogP	1.8
Synonyms	BDBM50420855
Inchi Key	GRGQEEUXMIDNPJ-MRXNPFEDSA-N
Inchi ID	InChI=1S/C21H35N5O5S/c1-16-14-24(20(27)31-21(2,3)4)10-11-26(16)19-22-12-18(13-23-19)30-15-17-6-8-25(9-7-17)32(5,28)29/h12-13,16-17H,6-11,14-15H2,1-5H3/t16-/m1/s1
PubChem CID	60155274
ChEMBL	CHEMBL2086668
IUPHAR	N/A
BindingDB	50420855
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	78.0 nM	PMID22545772	BindingDB,ChEMBL
Intrinsic activity	67.0 %	PMID22545772	ChEMBL

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