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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Oxoeicosanoid receptor 1
Species	Homo sapiens (Human)
Gene	OXER1
Synonym	R527 oxoeicosanoid (OXE) receptor 1 OXE receptor hGPCR48 GPR170 G-protein coupled receptor TG1019 G-protein coupled receptor R527 G-protein coupled receptor 170 5-oxo-ETE receptor 5-oxo-ETE G-protein coupled receptor TG1019 [ Show all ]
Disease	N/A
Length	423
Amino acid sequence	MLCHRGGQLIVPIIPLCPEHSCRGRRLQNLLSGPWPKQPMELHNLSSPSPSLSSSVLPPSFSPSPSSAPSAFTTVGGSSGGPCHPTSSSLVSAFLAPILALEFVLGLVGNSLALFIFCIHTRPWTSNTVFLVSLVAADFLLISNLPLRVDYYLLHETWRFGAAACKVNLFMLSTNRTASVVFLTAIALNRYLKVVQPHHVLSRASVGAAARVAGGLWVGILLLNGHLLLSTFSGPSCLSYRVGTKPSASLRWHQALYLLEFFLPLALILFAIVSIGLTIRNRGLGGQAGPQRAMRVLAMVVAVYTICFLPSIIFGMASMVAFWLSACRSLDLCTQLFHGSLAFTYLNSVLDPVLYCFSSPNFLHQSRALLGLTRGRQGPVSDESSYQPSRQWRYREASRKAEAIGKLKVQGEVSLEKEGSSQG
UniProt	Q8TDS5
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDS5
3D structure model	This predicted structure model is from GPCR-EXP Q8TDS5.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1628461
IUPHAR	271
DrugBank	N/A

Ligand

Name	CHEMBL3115774
Molecular formula	C20H26ClNO3
IUPAC name	5-(6-chloro-2-hexylindol-1-yl)-3-methyl-5-oxopentanoic acid
Molecular weight	363.882
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	5.5
Synonyms	3-Methyl-5-oxo-5-(2-hexyl-6-chloro-1H-indole-1-yl)pentanoic acid SCHEMBL286542 BDBM50446953 SCHEMBL10105432
Inchi Key	HIVUMAXJGBETMO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H26ClNO3/c1-3-4-5-6-7-17-12-15-8-9-16(21)13-18(15)22(17)19(23)10-14(2)11-20(24)25/h8-9,12-14H,3-7,10-11H2,1-2H3,(H,24,25)
PubChem CID	49802029
ChEMBL	CHEMBL3115774
IUPHAR	N/A
BindingDB	50446953
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	7.0 nM	PMID24351031, PMID25050171	BindingDB
IC50	7.0 nM	PMID24351031, PMID25050171	ChEMBL
IC50	18.0 nM	PMID24948567	BindingDB,ChEMBL
IC50	28.0 nM	PMID24351031	BindingDB,ChEMBL
IC50	30.0 nM	PMID24351031	BindingDB,ChEMBL
IC50	402.0 nM	PMID24351031	BindingDB,ChEMBL
IC50	2175.0 nM	PMID24351031	BindingDB,ChEMBL
Ratio	10.0 -	PMID24351031	ChEMBL

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