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GPCR

NameMotilin receptor
SpeciesHomo sapiens (Human)
GeneMLNR
SynonymGPR38
G protein-coupled receptor 38
G-protein coupled receptor 38
MTLR1
MTLR
[ Show all ]
DiseaseGastrointestinal disorders; Gastroesophageal reflux disease
Irritable bowel syndrome
Gastrointestinal disease
Gastroesophageal reflux disease
Gastric motility disorder
[ Show all ]
Length412
Amino acid sequenceMGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
UniProtO43193
Protein Data BankN/A
GPCR-HGmod modelO43193
3D structure modelThis predicted structure model is from GPCR-EXP O43193.
BioLiPN/A
Therapeutic Target DatabaseT62306
ChEMBLCHEMBL2203
IUPHAR297
DrugBankBE0003521

Ligand

NameSCHEMBL1704149
Molecular formulaC25H32ClFN4O
IUPAC name2-[3-chloro-4-[[(3S)-3-methylpiperazin-1-yl]methyl]phenyl]-1-[4-(3-fluoroanilino)piperidin-1-yl]ethanone
Molecular weight459.006
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP3.9
SynonymsCHEMBL2364290
Inchi KeyHOTLFLYDODUURG-SFHVURJKSA-N
Inchi IDInChI=1S/C25H32ClFN4O/c1-18-16-30(12-9-28-18)17-20-6-5-19(13-24(20)26)14-25(32)31-10-7-22(8-11-31)29-23-4-2-3-21(27)15-23/h2-6,13,15,18,22,28-29H,7-12,14,16-17H2,1H3/t18-/m0/s1
PubChem CID57586303
ChEMBLCHEMBL2364290
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC505.012 nMDOI: http://dx.doi.org/10.6019/CHEMBL2364262ChEMBL

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