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GPCR

NameMotilin receptor
SpeciesHomo sapiens (Human)
GeneMLNR
SynonymGPR38
G protein-coupled receptor 38
G-protein coupled receptor 38
MTLR1
MTLR
[ Show all ]
DiseaseGastrointestinal disorders; Gastroesophageal reflux disease
Irritable bowel syndrome
Gastrointestinal disease
Gastroesophageal reflux disease
Gastric motility disorder
[ Show all ]
Length412
Amino acid sequenceMGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
UniProtO43193
Protein Data BankN/A
GPCR-HGmod modelO43193
3D structure modelThis predicted structure model is from GPCR-EXP O43193.
BioLiPN/A
Therapeutic Target DatabaseT62306
ChEMBLCHEMBL2203
IUPHAR297
DrugBankBE0003521

Ligand

NameCHEMBL384698
Molecular formulaC31H42N4O4
IUPAC name(5R,8R,11S,16Z)-5-[(4-hydroxyphenyl)methyl]-8-propan-2-yl-11-propyl-4,7,10,13-tetrazabicyclo[16.4.0]docosa-1(22),16,18,20-tetraene-6,9,12-trione
Molecular weight534.701
Hydrogen bond acceptor5
Hydrogen bond donor5
XlogP4.9
SynonymsBDBM50199379
(E/Z)-(8R,11R,14S)-8-(4-hydroxy-benzyl)-11-isopropyl-14-propyl-5,7,8,10,11,13,14,16,17,18-decahydro-6H-7,10,13,16-tetraaza-benzocyclooctadecene-9,12,15-trione
Inchi KeyHPCVAFISJXNTEA-XVYFQXMKSA-N
Inchi IDInChI=1S/C31H42N4O4/c1-4-9-26-29(37)33-18-8-7-12-23-10-5-6-11-24(23)17-19-32-27(20-22-13-15-25(36)16-14-22)30(38)35-28(21(2)3)31(39)34-26/h5-7,10-16,21,26-28,32,36H,4,8-9,17-20H2,1-3H3,(H,33,37)(H,34,39)(H,35,38)/b12-7-/t26-,27+,28+/m0/s1
PubChem CID44417758
ChEMBLCHEMBL384698
IUPHARN/A
BindingDB50199379
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID17125271BindingDB,ChEMBL

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