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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 183
Species	Mus musculus (Mouse)
Gene	Gpr183
Synonym	GPR183 G protein-coupled receptor 183 Epstein-Barr virus-induced gene 2 Epstein-Barr virus-induced G-protein coupled receptor 2 homolog {ECO:0000250\|UniProtKB:P32249} EBV-induced G-protein coupled receptor 2 homolog {ECO:0000250\|UniProtKB:P32249} EBV-induced G protein-coupled receptor 2 EBI2 {ECO:0000250\|UniProtKB:P32249} EBI2 lymphocyte-specific G protein-coupled receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	357
Amino acid sequence	MANNFTTPLATSHGNNCDLYAHHSTARVLMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSMNLVISDILFTTALPTRIAYYALGFDWRIGDALCRVTALVFYINTYAGVNFMTCLSIDRFFAVVHPLRYNKIKRIEYAKGVCLSVWILVFAQTLPLLLTPMSKEEGDKTTCMEYPNFEGTASLPWILLGACLLGYVLPITVILLCYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFILCFTPYHVAIIQHMIKMLCSPGALECGARHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMKMLKRQVSVSISSAVRSAPEENSREMTESQMMIHSKASNGR
UniProt	Q3U6B2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3259471
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL3262893
Molecular formula	C23H26N2O3
IUPAC name	(E)-1-[4-(3,4-dimethylbenzoyl)piperazin-1-yl]-3-(4-methoxyphenyl)prop-2-en-1-one
Molecular weight	378.472
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	3.4
Synonyms	(E)-1-[4-(3,4-dimethylbenzoyl)piperazin-1-yl]-3-(4-methoxyphenyl)prop-2-en-1-one BDBM50011690
Inchi Key	ICVHOHKWQRXBSS-YRNVUSSQSA-N
Inchi ID	InChI=1S/C23H26N2O3/c1-17-4-8-20(16-18(17)2)23(27)25-14-12-24(13-15-25)22(26)11-7-19-5-9-21(28-3)10-6-19/h4-11,16H,12-15H2,1-3H3/b11-7+
PubChem CID	86579985
ChEMBL	CHEMBL3262893
IUPHAR	N/A
BindingDB	50011690
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	52.0 nM	PMID24678947	BindingDB,ChEMBL
IC50	52.48 nM	PMID24678947	ChEMBL

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