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GPCR

Name5-hydroxytryptamine receptor 7
SpeciesHomo sapiens (Human)
GeneHTR7
Synonym5-HT-7
Serotonin receptor 7
5-HT-X
5-HT1Y
5-HT7
[ Show all ]
DiseaseSleep disorders
Schizophrenia
Major depressive disorder
Length479
Amino acid sequenceMMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
UniProtP34969
Protein Data BankN/A
GPCR-HGmod modelP34969
3D structure modelThis predicted structure model is from GPCR-EXP P34969.
BioLiPN/A
Therapeutic Target DatabaseT79062
ChEMBLCHEMBL3155
IUPHAR12
DrugBankBE0000650, BE0004862

Ligand

Name8-OH-Dpat
Molecular formulaC16H25NO
IUPAC name7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
Molecular weight247.382
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogP4.1
SynonymsNCGC00024635-02
S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT
(+-)-8-OH-DPAT
142272-99-9
8-Hydroxy-DPAT
[ Show all ]
Inchi KeyASXGJMSKWNBENU-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
PubChem CID1220
ChEMBLCHEMBL56
IUPHAR7, 31
BindingDB21393
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki25.1189 - 501.187 nMPMID11414657, PMID9298538, PMID8226867, PMID9720804IUPHAR
Ki125.89 nMPMID9149537BindingDB
Ki141.25 nMPMID9298538BindingDB
Ki251.189 nMPMID9720804PDSP
Ki251.19 nMPMID9720804BindingDB
Ki388.0 nMPMID28063784, PMID25759032BindingDB,ChEMBL
Ki466.0 nMPMID8226867, PMID12825922PDSP,BindingDB,ChEMBL
Ki467.73 nMPMID7984267PDSP,BindingDB
Ki501.19 nMPMID9149537BindingDB

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